Elan Pharmaceuticals, Inc.

Eli Lilly and Company

Athena Neurosciences, Inc.

Other

The Brigham and Women's Hospital, Inc.

Neurocal International Inc.

Carmen Vigo-Pelfrey

Peter A Seubert

Dale Bernard Schenk

Robin McDaid Barbour

Dennis J Selkoe

Michael G Schlossmacher

Dale B Shenk

This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-&#x3b2; peptide (x&#x2212;&#x2267;41) in the cerebrospinal fluid of a patient. High levels of the peptide generally are inconsistent with a diagnosis of Alzheimer's. Low levels of the peptide are consistent with the disease and, with other tests, can provide a positive diagnosis. Other methods involve measuring the amounts of both A&#x3b2;(x&#x2212;&#x2267;41) and tau. Low levels of A&#x3b2;(x&#x2212;&#x2267;41) and high levels of tau are a positive indicator of Alzheimer's disease, while high levels of A&#x3b2;(x&#x2212;&#x2267;41) and low levels of tau are a negative indication of Alzheimer's disease.

Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-&#x3b2; peptide (x-&#x2267;41) and tau

This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-&#x3b2; peptide (x-&#x2267;41) in the cerebrospinal fluid of a patient. High levels of the peptide generally are inconsistent with a diagnosis of Alzheimer's. Low levels of the peptide are consistent with the disease and, with other tests, can provide a positive diagnosis. Other methods involve measuring the amounts of both A&#x3b2;(x-&#x2267;41) and tau. Low levels of A&#x3b2;(x-&#x2267;41) and high levels of tau are a positive indicator of Alzheimer's disease, while high levels of A&#x3b2;(x-&#x2267;41) and low levels of tau are a negative indication of Alzheimer's disease.

Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-&#x3b2; peptide (X-&#x3e;41) and tau

Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-&#x3b2; peptide (x-&#x2267;41) and tau

A method for identifying inhibitors of the production of &bgr;-amyloid peptides by administration of a compound to a mammalian host is provided.

Method for identifying &bgr;-amyloid peptide production inhibitors

This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-.beta. peptide (x-.gtoreq.41) in the cerebrospinal fluid of a patient. High levels of the peptide generally are inconsistent with a diagnosis of Alzheimer's. Low levels of the peptide are consistent with the disease and, with other tests, can provide a positive diagnosis.

Methods for aiding in the diagnosis of Alzheimer's disease by measuring

The present invention provides a method for treating patients with Alzheimer's Disease which comprises administering a an effective amount of a celastrol formulation to the patients. One source of raw material for such a celastrol formulation is the root of the vine tripterygium wilfordii Hook F.

Use of celastrol to treat alzheimer's disease

Soluble .beta.-amyloid peptide (.beta.AP) is measured in biological fluids at very low concentrations, typically in the range from 0.1 ng/ml to 10 ng/ml. The measurement of .beta.AP concentrations in animals or conditioned medium from cultured cells can be used for drug screening, where test compounds are administered to the animals or exposed to the cultured cells and the accumulation of .beta.AP in the animal or culture medium observed. It has been found that elevated levels of .beta.AP in body fluids, such as blood and cerebrospinal fluid, is associated with the presence of a .beta.AP-related condition in a patient, such as Alzheimer's Disease. Methods for diagnosing and monitoring .beta.AP-related conditions comprise measuring the levels of .beta.AP in such body fluids from a patient.

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Mountain View, CA, United States of America

Carmen Vigo-Pelfrey