Curis, Inc.

Harvard College

Carmen Pepicelli

Henryk T Dudek

Irina Karavanov

Lee L Rubin

Karen Kotkow

Andrew P McMahon

Paula Lewis

The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.

Methods of inhibiting unwanted cell proliferation using an antibody that binds to sonic hedgehog and inhibits hedgehog signaling

Methods of treating pancreatic or liver cancer using hedgehog antagonists

Methods of inhibiting unwanted cell proliferation using hedgehog antagonists

The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.

Regulation of lung tissue by patched therapeutics and formulations and uses related thereto

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Lowell, MA, United States of America

Carmen Pepicelli