University of Colorado

Carmen Giltner

Robert S Hodges

Randall Thomas Irvin

Erin Van Schaik

The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain oftype IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety ofstrains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.

Non-toxic biofilm inhibitor

The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain oftype IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety ofstrains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.

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St. Albert, Canada

Carmen Giltner