Caliper Life Sciences, Inc.

Other

Caliper Technologies Corporation

Carlton F Brooks

Morten Juel Jensen

Andrea W Chow

Michael A Spaid

Seth R Stern

Luc J Bousse

Allen R Boronkay

David J Chazan

Seth Stern

Yevgeny Yurkovetsky

Ken Swartz

Derek Louch

A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperature of the fluid within the microchannels is controlled in various ways including the use of electrical resistive heating elements and by providing zones located in contact with the top and bottom layers of the microfluidic device for circulating heat transfer of fluid therein.

Method and apparatus for improved temperature control in microfluidic devices

Methods and devices that include the use of venting elements for enhancing bonded substrate yields and regulating temperature. Venting elements are generally fabricated proximal to functionalized regions in substrate surfaces to prevent bond voids that form during bonding processes from affecting the functionalized regions. Venting elements generally include venting channels or networks of channels and/or venting cavities.

Methods and devices for enhancing bonded substrate yields and regulating temperature

Methods and systems for effecting a parameter and detecting a parameter using two electric signal in a conductive path are described.

Method and apparatus for controllably effecting samples using two signals

Methods and devices for inducing high bulk hydrodynamic resistance and/or for inducing low electrical resistance in microscale systems including bulk viscosity enhancers, surfactants, and electrolytes. High bulk hydrodynamic resistance is optionally utilized to regulate the effects of spontaneous injection and/or dispersion. Induced high hydrodynamic resistance in conjunction with induced low electrical resistance are optionally utilized to provide and regulate electrical fields within microfluidic devices. Integrated systems incorporating the methods of the invention are also provided.

Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers

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San Jose, CA, United States of America

Carlton F Brooks