Alter, S.a.

Cermol S.a.

Carlos Sunkel Letelier

Shyam Sunder Chatterjee

Danielle Straumann

Julio Alvarez-Builla Gomez

Fernando Cillero Grafulia

Pierre Statkow

Fernando CilleroGrafulla

Jos&eacute; M Minguez Ortega

Miguel Fau De Casa-Juana Munoz

Fernando Cillero Grafulla

Pyridyl compounds and pharmaceutical compositions containing them

This invention provides a process for the preparation of glycol 2-(p-chlorophenoxy)-2-methylpropionate nicotinate, of formula (I): ##STR1## which process is characterized in that 2-(p-chlorophenoxy)-2-methylpropionic acid, of formula (II): ##STR2## is reacted with ethylene oxide in an inert solvent in the presence of a catalyst, to prepare the monoglycol ester of the acid (II), of formula (III): ##STR3## which is in turn reacted with nicotinic acid chloride in an inert solvent and in the presence of a base, to prepare the final product, of formula (I).

Preparation of glycol

The present invention is concerned with purifying the mixed ester, ethylene glycol 1-/2-(p-chlorophenoxy)-2-methylpropionate/-2-nicotinate by passing said compound in oily form through a layer of Super-Cel and charcoal and then crystallizing said compound from a mixture of benzene/petroleum ether. This compound has hypolipidemic properties.

Process for purifying the mixed ester, ethylene glycol

The o-acetoxy benzoate ester of 2(p-acetamido-phenyloxy)-ethyl alcohol.

O-Acetoxy benzoate ester of 2(p-acetamido-phenyloxy)ethyl alcohol

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Madrid, Spain

Carlos Sunkel Letelier