Solvotrin Therapeutics Limited

The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near Dublin

Carlos Medina Martin

Mark Ledwidge

John Francis Gilmer

Pat O'Flynn

Shona Harmon

Marek Radomski

A compound having the structural formula (I) and pharmaceutically acceptable salt and/or hydrates thereof, (I) wherein Y is an arylester or an C-Calkylaryl ester, selected from the group consisting of: benzene, toluene, xylene, benzoic acid, benzoate, nicotinate, isonicotinate and halobenzene, which can be unsubstituted or substituted with at least one nitric oxide releasing group; and/or at least one of hydroxide, &#x2014;Cl, &#x2014;Br, a C-Calkyl, benzyl, a C-Calkoxy, benzyloxy, &#x2014;NHC(O)R, &#x2014;NH, &#x2014;NO, &#x2014;ONO, &#x2014;(CH)ONO, &#x2014;OC(O)[(CH)m], cyclic ONO, &#x2014;OCOArONO, &#x2014;OCOAr(CH)ONOor a C-Chaloalkyl ester, wherein R is a C-Calkyl or a C-Calkoxy group, n=1-8 and m=3-10, to produce a super-aspirin effect.

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Dublin, Ireland

Carlos Medina Martin