University of Pittsburgh

Carlos Jaime Camacho

Elias Aizenman

Adam C Straub

Mizanur Rahaman

Robin E C Lee

Fabio Reinders

Disclosed herein are small molecule compounds capable of disrupting Kv2.1-syntaxin binding. The compounds are useful for treating a variety of neurological disorders, diseases, and injuries.

Neuroprotective disruption of Kv2.1/syntaxin interaction by small molecules

Provided herein are small molecules that specifically inhibit TNF-induced nuclear factor kB (NF-kB) inflammation pathway. Also provided are methods of screening compounds to identify molecules that specifically inhibit a TNF-induced NF-kB inflammation pathway, methods of inhibiting TNF-induced NF-kB inflammation pathway, and methods of preventing formation of mature TNFR1 complex.

Small molecules that specifically inhibit TNF-induced NF-KB inflammation pathway

A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: 

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Pittsburgh, PA, United States of America

Carlos Jaime Camacho