Glaxo Wellcome Inc.

Carlos Estenio Hormaeche

Steven Neville Chatfield

Kevin Stuart Johnson

Ian George Charles

Gordan Dougan

Gordon Dougan

Attenuated microorganism for use in immunoprophylaxis in which the attenuation is brought about by the presence of a mutation in the DNA sequence of the microorganism which encodes, or which regulates the expression of DNA encoding a protein that is produced in response to environmental stress, the microorganism optionally being capable of expressing DNA encoding a heterologous antigen.

Vaccines containing bacteria attenuated by mutation of the htrA gene

An attenuated microorganism harboring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can be genetically engineered so as to express antigens from other pathogens and thus form the basis of a range of multi-valent vaccines.

Vaccines containing bacteria attenuated by mutations in two genes of the

Vaccines containing a salmonella bacteria attenuated by mutation of the

An attenuated microorganism harbouring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can be genetically engineered so as to express antigens from other pathogens and thus form the basis of a range of multi-valent vaccines.

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Cambridge, United Kingdom

Carlos Estenio Hormaeche