Massachusetts Institute of Technology

Universidad Politécnica De Madrid

Leuko Labs, Inc

Carlos Castro-Gonzalez

Ian Butterworth

Aurelien Bourquard

Alvaro Sanchez Ferro

Alberto Pablo-Trinidad

Alvaro Sanchez-Ferro

Tom Vettenburg

Ganimete Lamaj

Nolan Bell

Jason Tucker-schwartz

Alberto Pablo Trinidad

Maria J Ledesma Carbayo

Jason Michael Tucker-Schwartz

Cedric Gobber

Ramon Martinez De Sarasa Pardas

Maria J Ledesma-Carbayo

Ryan Benasutti

A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Systems, devices and methods for non-invasive hematological measurements

An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed.

Automated system for acquiring images of one or more capillaries in a capillary bed

Non-invasive white blood cell monitoring device

Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.

Systems, apparatus, and methods for analyzing blood cell dynamics

Growing community of inventors

Cambridge, MA, United States of America

Carlos Castro-Gonzalez