Sylentis Sau

Diverdrugs, S.l

Carlos Belmonte Martínez

Cristina Carreño Serraïma

Wim Van Den Nest

Antonio Ferrer Montiel

Ana Isabel Jimenez Anton

María Concepción Jiménez Gomez

Angela Sesto Yague

Juana Gallar Martinez

Asia Fernández Carvajal

Carolina Garcia Martínez

Ana Isabel Jiménez Antón

Maria Del Carmen Acosta Boj

Maria Del Acosta Boj

Maria Concepción Jiménez Gómez

The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy.

Modulation of TRPV expression levels

The invention relates to compounds having formula (I), which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, a production method thereof and compositions containing same. According to the invention, Ar is a phenyl group substituted with one or more halogen groups; Ris amino, hydroxyl or thiol, all of which may or may not be substituted with formula (II) or with aliphatic or cyclic groups; Ris H or an alkyl, aryl, aralkyl or acyl group or formula (III); Ris H or formula (IV); Rand Rare H or an aliphatic or cyclic group; Ris H or formula (V); Ris H or an aliphatic or cyclic group; Z is amino, hydroxyl or thiol, all of which may or may not be substituted with aliphatic or cyclic groups; W is a linkage or formula (VI); X is a linkage or formula (VII); Y is amino which may or may not be substituted with formula (VIII) or an alkyl, aryl, aralkyl or acyl group; m, q and s can vary between 1 and 9 and n and p can vary between 1 and 10 

Compounds which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, production method thereof and compositions containing same

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Alicante, Spain

Carlos Belmonte Martínez