Genentech, Inc.

F. Hoffmann-la Roche Ag

Carlos Bais

Richard Bourgon

Thomas Sandmann

Heidi S Phillips

Maike Schmidt

Mallika Singh

Matthew Brauer

YounJeong Choi

Yuanyuan Xiao

Nicola C Consalvo

Heidi Phillips

This invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic.

Combination therapy for the treatment of glioblastoma

The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

Diagnostic methods and compositions for treatment of glioblastoma

The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

Biological markers for identifying patients for treatment with VEGF antagonists

Method of treatment for glioblastoma by administering a VEGF antagonist

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South San Francisco, CA, United States of America

Carlos Bais