Lawrence Livermore National Security, LLC

Rigel Pharmaceuticals, Incorporated

Carlos A Valdez

Rajinder Paul Singh

John Yudhistir Ramphal

Kin Tso

Rao Kolluri

Haoran Zhao

Brian P Mayer

Edmond Y Lau

Hui Li

Joe H Satcher, Jr

Somasekhar Bhamidipati

Jeffrey Clough

Darren J McMurtrie

Sambaiah Thota

Roger D Aines

Sarah Elyse Baker

Marina Gelman

Andy Atuegbu

John Ramphal

Henry Eugene Rogers

Matthew Duncton

Jing Zhang

Salvador Alvarez

Felice C Lightstone

Roald N Leif

Francesco Fornasiero

Alexander K Vu

Shihai Gu

Emily Stauffer

Heather Ann Enright

Daniel Joseph Kennedy

Tuan H Nguyen

Nicholas A Be

Brian J Bennion

Joshuah K Stolaroff

Bonnee Rubinfeld

William C Floyd, Iii

Sergio E Wong

Todd Anthony Stair

Lawrence Dugan

Tammy Olson

Thomas Yong-Jin Han

Brian E Souza

Timothy S Carpenter

Mathew Gerald Lyman

Sung Ho Kim

Jimmy Venizelos

Margaret Windy McNerney

Gary J Makowiecki

Tim Carpenter

Saphon Hok

Mike Malfatti

Hio Leong Lao

Audrey M Williams

Huí Li

John Despotopulos

Kelly Nora Kmak

Michael A Malfatti

Darren Mcmurtrie

A method of forming a chemically reactive membrane includes applying a first solution to a structure, the first solution includes a macrocyclic ligand having electron-donating ligands and a side functional group for crosslinking, crosslinking a plurality of the macrocyclic ligand to form a first network of crosslinked macrocyclic ligands, and applying a second solution to the structure, the second solution comprising a catalytic center. Each catalytic center complexes with the electron-donating ligands of each macrocyclic ligand to form catalytic sites in the first network of crosslinked macrocyclic ligands.

Reactive membrane networks for CWA protection

A shoe track assembly system includes an elongated housing extending from a first end to a second end; one or more valves secured within the elongated housing; one or more plug landing seats extending into the elongated housing; one or more plugs to be dropped into the elongated housing and engage with the one or more plug landing seats; the system is to receive casing pressure testing without relying on a shoe track cement integrity; and the system is to contain all required shoe track equipment as required by an operation.

Shoe track assembly system and method of use

A tool and method for selectively allowing a transmission of torque to a casing string at a position below installation of the tool along the casing string. The tool includes an upper body to engage with an upper portion of a casing string, a lower body to engage with a lower portion of a casing string, and a swivel assembly connecting the upper body to the lower body, the swivel assembly is to operate in multiple configurations such that the upper body and the lower body are selectively locked together to allow or prevent torque transmission through the tool from the upper portion of the casing string to the lower portion of the casing string.

Integral swivel for multiple stage cementing tools apparatus and method of use

A membrane includes a first layer, and a second layer coupled to the first layer. The second layer includes a network of catalytic sites, each catalytic site having a catalytic center characterized by promoting a chemical reaction of a target material. A method of forming a chemically reactive membrane includes applying a first solution to a structure, the first solution includes a macrocyclic ligand having electron-donating ligands and a side functional group for crosslinking, crosslinking a plurality of the macrocyclic ligand to form a first network of crosslinked macrocyclic ligands, and applying a second solution to the structure, the second solution comprising a catalytic center. Each catalytic center complexes with the electron-donating ligands of each macrocyclic ligand to form catalytic sites in the first network of crosslinked macrocyclic ligands.

Provided herein are methods of isolating and using radioactive mercury. In particular, provided herein are methods of isolating radioactive mercury including the use of a thiacrown ether, and using the isolated radioactive mercury in therapeutic and/or imaging applications.

Methods of isolating radioactive mercury and uses thereof

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh&#x2212;Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB).

Biodegradable surfactants and related compositions, methods and systems

Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.

Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Novel thioalkylcarboxylate-modified CDs and pharmaceutical compositions comprising these thioalkylcarboxylate-modified CDs are disclosed, as well as methods of using the disclosed thioalkylcarboxylate-modified CDs and pharmaceutical compositions thereof to neutralize or reduce undesired effects or symptoms associated with one or more fentanyl related compounds in a subject in need thereof. The use of the disclosed thioalkylcarboxylate-modified CDs to detect the presence of one or more fentanyl related compounds in a sample is also disclosed, which comprises contacting the sample with said thioalkylcarboxylate-modified CDs or a composition comprising these CDs.

Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof

A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.

Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same

In one embodiment, a method includes contacting a phosphotriester and a halogen salt in a polar solvent. In another embodiment, a method for dealkylating tributylphosphate includes contacting tributylphosphate and a halogen salt in a polar solvent.

Halide-mediated dealkylation of phosphotriesters

Provided herein are methods for sequestering an alkyne-presenting molecule in a sample and related sequestration reagents, compositions, methods and systems.

Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods

Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.

Methods for the selective detection of alkyne-presenting molecules and related compositions and systems

Growing community of inventors

San Ramon, CA, United States of America

Carlos A Valdez