University of California

City University of New York

Carlos A Meriles

Alexander Pines

Dimitrios Sakellariou

Daniela Pagliero

Abdelghani Laraoui

Ashok Ajoy

Raffi Nazaryan

Rachel W Martin

Adam Moule

Andreas H Trabesinger

Henrike Heise

Xudong Lv

Daniel Topgaard

A method of hyperpolarizing diamond particles includes applying a laser to a sample of the diamond particles, irradiating the diamond particles with a sweeping microwave to cause diamond polarization, shuttling the diamond particles through a magnetic field to detectC nuclei in the diamond particles, and relaying the diamond polarization to nuclear spins to one of a surrounding solid or fluid.

Orientation independent, room temperature, hyperpolarization of diamond nano- and micro-particles

A method of inducing spin polarization in an analyte is provided. The method exposesN spin defect centers embedded within 25 nm of a diamond surface to a magnetic field while an analyte is near the surface. TheN spin defect centers are polarized by treatment with an electromagnetic wave protocol having a visible light pulse (p); a microwave pulse (mw), a radio frequency pulse (rf), a microwave pulse (mw) and a radio frequency pulse (rf) resulting in polarization of the nuclear spins of theN spin defect centers. Polarized spins in theN spin defect centers induce spin polarization in the analyte.

Method for inducing spin polarization in an analyte usingN spin defect centers

A method and apparatus for polarizing nuclear or electronic spins is disclosed. An analyte is passed near a surface that has a plurality of spin defect centers implanted within 10 nm of the surface. The spin defect centers are exposed to a magnetic field and illumination to produce polarized spins. The polarized spins then induce spin polarization in the analyte.

Method and apparatus for polarizing nuclear and electronic spins

[object Object]

A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.

Low field magnetic resonance imaging

Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.

Nuclear magnetic resonance detection in inhomogeneous magnetic fields

A probe, device, and methods for performing nuclear magnetic resonance (NMR) measurements on a suitable sample are provided. The probe includes a hyper polarized tip positioned to cause a dipolar interaction between the tip and sample. The nuclear magnetic spin of a selected portion of the sample induces a modulation of tip magnetization, which is proportional to the local magnetization of the selected portion. An NMR device includes the probe, a radio frequency (RF) coil for manipulating spins in the sample and tip, and a means for detecting the modulation of tip magnetization. An RF pulse sequence selects the selected portion and allows detection of the modulation. The method for obtaining NMR data includes positioning the tip to induce the dipolar interaction; selecting the sample portion; modulating the tip magnetization in response thereto; and detecting the tip modulation. The device and method may be adapted to obtain NMR images and spectroscopy.

Method and apparatus for high resolution nuclear magnetic resonance imaging and spectroscopy

A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.

Growing community of inventors

Fort Lee, NJ, United States of America

Carlos A Meriles