Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Istituto Luso Farmaco D'italia

Other

Bracco Imaging S.p.a.

Neopharmed S.p.a.

Lpb Istituto Farmaceutico

Cisi Scrl

L'instituto Farmaceutico S.p.a.

Lbp Istituto Faraceutico S.p.a.

501 Sigma Tau Industrie Farmaceutiche Riunite S.p.a.

Carlo Scolastico

Aldo Salimbeni

Maria Ornella Tinti

Giuseppe Giannini

Domenico Misiti

Leonardo Manzoni

Cesare Sirtori

Giovanni Tronconi

Fulvio Uggeri

Luciano Lattuada

Silvio Aime

Enzo Terreno

Pierfrancesco Morosini

Daniela Delli Castelli

Carlo A Bagolini

Davide Poma

David Kritchevsky

Daniela Arosio

Jacques Mizrahi

Fabio Giannessi

Elso Manghisi

Orlando Ghirardi

Pierfausto Seneci

Martino Bolognesi

Eloise Mastrangelo

Carmelo Drago

Domenico Delia

Renato Canevotti

Laura Belvisi

Roberto Cozzolino

Fabio Paleari

Anna Renzetti

Ilaria Motto

Piero Gomarasca

Gabriele Braglia

Mario De Mayo De Mari Milani

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

Integrin targeted synthetic ligands for diagnostic and therapeutic applications

The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.

SMAC mimetic compounds as apoptosis inducers

Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors

The present invention discloses compounds of formula (I)

Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.

Pyrimidinone derivatives fused to nitrogen heterocycles having a II

Imidazole derivatives having a II antagonist activity

Compounds having angiotensine II antagonistic activity

Imidazole ethers having a II antagonist activity

Pharmaceutical compositions for enhancing the process of learning and memory are disclosed, that contain as active principle a 3-amino-.epsilon.-caprolactam of formula (1) ##STR1## Wherein R is selected from the group consisting of hydrogen, formyl and acetyl. Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of a compound of formula (1).

Pharmaceutical compositions comprising 3-amino-.epsilon.-caprolactames

L-aminoacyl derivatives of L-carnitine of general formula (I) ##STR1## wherein R is an alkyl radical selected from 1-methyl-propyl, isobutyl, isopropyl, mercaptomethyl and 3-guanidino propyl, and their pharmacologically acceptable salts, are prepared e.g. by reacting a solution in an organic solvent of L-carnitine whose carboxyl group is protected with an N-protected aminoacid in the presence of a condensing agent and then removing the amino-acid and carnitine protecting groups, thus obtaining the desired compound.

Derivatives of L-amino acyl L-carnitine, process for their preparation

The diacylesters, particularly bis(pyridyl-3-carboxilate) of glycerylphosphorylcholine, both optically active L(alpha) or racemic D,L(alpha) and their complexes having general formula: ##STR1## wherein: Y represents ##STR2## M represents Ca, Mg, Al, Zn X represents a halogen, particularly chlorine, n=2,3 ed m=0,1 are anti-dislipemic and cerebroactive agents. Their preparation takes place through acylation with an anhydride of a complex of glycerylphosphorylcholine with calcium or zinc chloride.

Complexes of glycerylphosphorylcholine

L-aminoacyl derivatives of L-carnitine of general formula (I) ##STR1## wherein R is an alkyl radical selected from 1-methyl-propyl, isobutyl, isopropyl, mercaptomethyl and 3-guanidino propyl, and their pharmacologically acceptable salts, are prepared e.g. by reacting a solution in an organic solvent of L-carnitine whose carboxyl group is protected with an N-protected aminoacid in the presence of a condensing agent and then removing the aminoacid and carnitine protecting groups, thus obtaining the desired compound.

The diacylesters, particularly bis(pyridyl-3-carboxilate) of glycerylphosphorylcholine, both optically active L(alpha) or racemic D, L(alpha) and their complexes having general formula: ##STR1## wherein: Y represents ##STR2## M represents Ca, Mg, Al, Zn X represents a halogen, particularly chlorine, n=2,3 ed m=0,1 are anti-dislipemic and cerebroactive agents. Their preparation takes place through acylation with an anhydride of a complex of glycerylphosphorylcholine with calcium or zinc chloride.

Diacyl derivatives of glycerylphosphorylcholine, their preparation, and

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Milan, Italy

Carlo Scolastico