Roche Diagnostics Operations, Inc.

Zeptosens Ag

Roche Diagnostics Gmbh

Ciba-Geigy Corporation

Other

Roche Diagnositcs Operations, Inc.

F. Hoffmann-La Roche Ag

Carlo S Effenhauser

Andreas Manz

D Jed Harrison

Karl-Heinz Koelker

Frank Deck

Heinz-Michael Hein

Herbert Harttig

Emad Sarofim

Patrick Griss

Gregor Ocvirk

Stephan Korner

Peter Kraemer

Christoph Boehm

Manfred Augstein

Gert Ludwig Duveneck

Norbert Oranth

Tony Ziegler

Edwin Oosterbroek

Remo Anton Hochstrasser

Michael Glauser

Alois Rainer

Peter Berndt

Mario Curcio

Alfredo E Bruno

Rijk Edwin Oosterbroek

Susanne Wuerl

Hanno Langen

Alfredo Emilio Bruno-Raimondi

Peter Oroszlan

Erich Haendler

Wolfgang Fiedler

Roger Sandoz

Ren&eacute; D&auml;ndliker

Francois Maystre

Beat Krattiger

Aran Paulus

Albert Roeder

Hans-Peter Herzig

Philippe Nussbaum

Kees Ensing

Hans-Joachim Hoeltke

Reinhard V&ouml;lkel

Christoph BÖHM

Susanne WÜRL

Griss Patrick

Micheal Glauser

A device for sampling, transporting and/or disposal of fluid media in the nl and &#x3bc;l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

Bent microstructures for sampling, transporting or dispensing a fluid media

A microfluidic device is provided including at least one chamber accessible by microfluidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.

Micro chamber

A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

Microfluidic element for analyzing a liquid sample

A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.

System for withdrawing small amounts of body fluid

A device for sampling, transporting and/or disposal of fluid media in the nl and &#x3bc;l-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

A micro fluidic device comprises a laminate structure, comprising a plurality of individual layers. At least one layer comprises a micro fluidic channel structure and at least on one side of said layer a further layer is arranged comprising a three-dimensional (3D) micro structure such that the 3D micro structure is influencing a flow characteristic of a fluid within the micro fluidic channel structure.

Fluidic device containing 3D structures

The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.

Method and apparatus for analyzing a dry-chemical test element

A microfluidic device for controlling sample introduction in microcolumn separation techniques, more particularly in capillary electrophoresis (CE), where a sample is injected as a sample plug into a sampling device which comprises at least a channel for the electrolyte buffer and a supply and drain channel for the sample. The supply and drain channels discharge into the electrolyte channel at respective supply and drain ports. The distance between the supply port and the drain port geometrically defines a sample volume. The injection of the sample plug into the electrolyte channel is accomplished electrokinetically by applying an electric field across the supply and drain channels for a time at least long enough that the sample component having the lowest electrophoretic mobility is contained within the geometrically defined volume. Means are provided for electrokinetically injecting the sample into the sample volume.

Microfluidic device for controlling sample introduction in microcolumn separation techniques and sampling device

The invention concerns a device which is used to separate gas or liquid from microfluidic flow-through systems. The gas or liquid separation is achieved independently of the spatial orientation of the device. In addition the invention concerns a microfluidic flow-through system in which a device according to the invention enables bubble-free fluid transport.

Device for extracting gas or liquid from microfluidid through-flow systems

A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation elementfor the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in areaof a separation plane. According to the invention it is proposed that the separation elementhas a channel or transfer structurefor the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surfacethat is preferably suitable for mass spectroscopic analyses.

Separation method and device for protein mixtures

A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

Method and separating module for the separation of particles from a dispersion, in particular of blood corpuscles from blood

The present invention generally relates to a system for withdrawing small amounts if body fluid from an animal or human. The system comprises a holder and a disposable lancing unit attached to the holder. The lancing unit also comprises an open capillary channel for transporting the body fluid and piercing the skin.

Growing community of inventors

Weil am Rhein, Germany

Carlo S Effenhauser