Fidia Farmaceutici S.p.a.

Carlo Pizzocaro

Anna Maria Zanellato

Monica Campisi

Cristian Guarise

Antonio Rosato

Massimiliano Corsini

Daniela Jabes

Giorgio Mosconi

A pharmaceutical composition is described, essentially consisting of the paclitaxel prodrug associated with pharmacologically acceptable diluents/excipients, for use in the treatment of non-muscle invasive bladder cancer (NMIBC) by means of intravesical instillations according to a single weekly dose of 600 mg of said prodrug, or two weekly doses equal to a total of 1,200 mg, for 12 or 6 consecutive weeks of treatment. The paclitaxel prodrug used was prepared according to an indirect synthesis process between molecules of hyaluronic acid (HA) and paclitaxel by introducing a spacer (4-bromobutyric acid) between the hyaluronic acid and chemotherapeutic agent.

Paclitaxel-hyaluronic acid conjugate in the treatment of non-muscle invasive bladder cancer

Disclosed are alkenylamides of sulfated hyaluronic acid and their use for the stabilisation and release of medicaments in the form of micellar suspensions which can be administered locally and/or locoregionally, in particular intra-articularly.

Stabilisation and controlled-release systems for medicaments unstable on sterilisation

A comminuting device of biological material includes a casing that contains fixed cutting elements and movable cutting elements cooperating with each other to grind biological material, a collecting chamber for ground biological material, and a partition wall adjacent to the collecting chamber. The fixed and movable cutting elements are above the partition wall together with the biological material to be ground. The collecting chamber is below the partition wall. The fixed cutting elements are in the form of elongated corners that extend radially. The movable cutting elements are in the form of elongated corners that extend radially. The partition wall is provided with wall portions. Calibrated holes are provided for the passage of biological material ground by the fixed cutting elements and the movable cutting elements. The collecting chamber is in connection with the outside of the casing through at least a channel.

Comminuting device of biological material and relative method for comminuting and cellular preparations

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Abano Terme, Italy

Carlo Pizzocaro