Ministero Dell'universita E Della Ricerca Scientifica E Tecnologica

Istituto Guido Donegani

Carlo Pina

Daniele Bianchi

Pietro Cesti

Aldo Bosetti

Ezio A Battistel

Paolo Golini

A process is described for separating the optical isomers of 1,2-isopropylideneglycerol, of formula (I), comprising partially stereoselective enzymatic hydrolysis of 1,2-isopropylideneglycerol benzoyl ester (II) catalyzed by a free or immobilized lipase, the hydrolysis being conducted in the presence of a cosolvent and followed by crystallization enabling crystals of (II) in raceme form and mother liquor containing (II) in the form of the pure enantiomer to be selectively obtained. The compound (I) is widely used industrially as an intermediate in the synthesis of chiral drugs such as (R)-(-)-carnitine, (S)-beta-blockers, (S)-antiviral agents, analgesic drugs etc.

Process for preparing (R) and (S)-1,2-isopropylideneglycerol by

Continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid consisting in the reaction of a racemic (R,S) ester of 2-(6-methoxy-2-naphthyl) propionic acid having melting point below 50.degree. C. of formula: ##STR1## wherein R.sub.1 =a C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.6 cycloalkyl, phenyl, tetrahydropyranyl , tetrahydrofuranyl radicals and

Process for the continuous biotechnological preparation of optical

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Milan, Italy

Carlo Pina