Advanced Accelerator Applications Sa

Advanced Accelerator Applications

Bracco Imaging S.p.a.

Laboratori Guidotti S.p.a.

Malesci Istituto Farmacobiologico S.p.a.

Centro Interuniversitario Di Ricera Sui Peptidi Bioattivi-universita'

A. Menatini Industrie Farmaceutiche

Carlo Pedone

Michele Saviano

Maria Caterina Turco

Luca Domenico D'Andrea

Vincenzo Pavone

Laura Zaccaro

Annarita Del Gatto

Angelina Lombardi

Carlo Alberto Maggi

Mario De Rosa

Laura Quartara

Stefania De Luca

Giancarlo Morelli

Diego Tesauro

Compounds of general formula (1): X1Y1X2Y2X3Y3X4Y4Y5X5X6Y6X7Y7X8X9X10 wherein X1-X10 are any natural or unnatural amino acids and Y1 is Gln; Y2 is Met or Leu; Y3 is He; Y4 is Pro or Ser; Y5 is His or Gly; Y6 is Gln or Pro; Y7 is He or Tyr or their homolog or ortolog are described; these compounds are able to bind to the VEGF receptors and to modulate the angiogenesis mediated by the VEG.

Compounds modulators of VEGF activity and uses thereof

The present invention is related to new peptide antagonists of &#x3b1;&#x3b2;receptor, designed on the basis of the crystal structure of integrin &#x3b1;&#x3b2;in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the &#x3b1;&#x3b2;receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for &#x3b1;&#x3b2;-targeted therapy and imaging.

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Selective &#x3b1;v&#x3b2;3 receptor peptide antagonist for therapeutic and diagnostic applications

This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The compounds of the present invention are used as diagnostic agents to identify and locate primary tumours and their metastases which over-express type A and/or B cholecystokinin receptors, and as therapeutic agents and cholecystokinin agonists or antagonists.

Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours

Soluble tachykinin antagonists, the preparation and use thereof

Tachyikinin antagonist compounds of the general formula: ##STR1## are described where: X1, X2, X3, X4, X5, and X6 are identical or different and are --NR'--CO-- or --CO--NR'--, where R' is H or C.sub.1-3 alkyl;

Tachiquinine antagonist tricyclic compounds, preparation of same and

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Naples, Italy

Carlo Pedone