Farmitalia Carlo Erba

Other

Carlo Passarotti

Carmelo Gandolfi

Franco Faustini

Roberto Ceserani

Angelo Fumagalli

Gianfederico Doria

Alessandro Andreoni

Maria M Usardi

Ada Buttinoni

Giuliana Arcari

Maria L Corno

Pier P Lovisolo

William Fava

Roberto Cesarani

Franco Fanstini

Allesandro Andreoni

The present invention relates to new condensed benzopyrone derivatives having a 5-tetrazolyl substituent thereon, and to pharmaceutical compositions containing them. The compounds are useful in the treatment of allergic conditions.

Condensed benzopyrone derivatives

Carboxy-thiazolo[3,2-a]pyrimidine derivatives, and pharmaceutical compositions containing them. The compounds and compositions possess anti-allergic activity.

Substituted carboxy-thiazolo[3,2-a]pyrimidine derivatives

The present invention relates to new condensed benzopyrone derivatives, to a process for their preparation and to pharmaceutical compositions containing them.

Amino derivatives of benzylidene-Pyrrolo[2,1-b] Quinazolines are provided, together with pharmaceutical compositions containing them. The compounds and the compositions have pharmaceutical utility and are particularly useful as anti allergy agents.

Amino derivatives of benzylidene-pyrrolo[2,1-b]quinazolines useful for

Substituted carboxy-thiazolo [3,2-a] pyrimidine derivatives are disclosed, together with compositions containing them and methods of using. These derivatives are useful as anti-allergic agents.

Substituted carboxy-thiazolo [3,2-a] pyrimidine derivatives and process

Omega furyl prostenynoic acids have been prepared.

13,14-Didehydro-prostaglandins and process for their preparation

Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha.- and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R' are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents substituted pyrrole, substituted phenyl or substituted thiazolyl. The compounds have antiinflammatory, antiulcerorgenic and antigastric secretory activity.

Substituted thiazolo[3,2-a]pyrimidines and process for their preparation

Compounds of the formula (I) ##STR1## wherein R.sub.1 is

Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions

The present invention relates to new carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, to a process for their preparation and to pharmaceutical (i.e. anti-inflammatory and analgesic) compositions containing them. The invention provides compounds having the following general formula (I) ##STR1## wherein R.sub.1 represents:

Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines,

Compounds of the formula (1) ##STR1## wherein n is 1 or 2;

Condensed cycloaliphatic derivatives of substituted

Compounds of the formula (I) ##STR1## wherein R.sub.1 is:

Substituted ethenyl derivatives of 1H-pyrazolo-[1,5-a]pyrimidine having

Compounds of general formula (I) ##STR1## wherein R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group; (b) a phenyl ring, unsubstituted or substituted by one or two groups chosen from halogen, trihalo-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.6 alkyl, nitro, amino and C.sub.2 -C.sub.6 alkanoylamino; (c) benzyl; or (d) C.sub.1 -C.sub.6 alkyl;

Substituted 1H-pyrazolo (1,5-a) pyrimidines and process for their

Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha. and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen or halogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R' are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents pyridyl optionally substituted by alkyl. The compounds have antiinflammatory, antiulcerogenic and anti-gastric secretory activity.

Substituted Pyrrolo [2,1-b] and Pyrido [2, 1 b] Quinazolines are provided, together with pharmaceutical compositions, containing them. The compounds have pharmaceutical utility, and are particularly useful for the treatment of or prevention of the formation of gastrointestinal ulcers.

Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines

2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of pharmacological utilities, such as hypotensive agents, vasodilatory agents, and anti-aggregating agents.

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Gallarate, Italy

Carlo Passarotti