Instituto Farmacologico Lombardo-Iflo, S.a.s.

Bmg Pharma Srl

Carlo Introini

Franco Fraschini

Bojidar Stankov

Gianluca Braguti

Maria T Moni, Heir

Ermanno Duranti, Deceased

Aldo Laguzzi

Margherita Borgonovo

Giorgio Delsignore

The novel compounds of formula: ##STR1## in which R is isopropyl, cyclohexyl, phenyl, CH.sub.3, Br or I; or H R.sub.1 is CH.sub.3 or cyclopropyl and R.sub.2 is H or Br, and when R.sub.1 is cyclopropyl and R.sub.2 is H, R is other than H, and when R.sub.1 is CH.sub.3 and R.sub.2 is H, R is other than H, and when R.sub.1 is CH.sub.3 and R.sub.2 is H, R is other than I, and when R is CH.sub.3 and R.sub.2 is H, R.sub.1 is other than CH.sub.3, and when R is phenyl and R.sub.2 is H, R.sub.1 is other than CH.sub.3, exhibit superior activity in the treatment of pathologies which interfere with the circadian rhythm. A novel method of preparation is described according to which the pharmaceutical compositions containing the novel compounds, as well as compounds already known, are administered transdermally. The novel method of administration results in sustained peripheral blood level. Novel pharmaceutical compositions are described suitable for transdermal administration.

Compounds effective in the treatment of circadian rhythms and related

Growing community of inventors

Milan, Italy

Carlo Introini