Hoechst Aktiengesellschaft

Carlo Giani

Susanne Grabley

Gerhard Seibert

Dieter Wullbrandt

Wolfgang Raether

Johannes Meiwes

Peter Hammann

Joachim Wink

Axel Zeeck

Hartmut Voelskow

Burkhard Sachse

Reinhardt Rothert

Susanne Dobreff

Gerhard Kretzschmar

Fritz Wagner

Dieter Duwel

Siegmund Lang

Andreas Brakemeier

Pia Kricke-Helling

The present invention relates to glucose- and sophorose-lipids of the formula I ##STR1## in which R.sup.4 is --OH or a group of the formula II, ##STR2## n is an integer from 2 to 26, R.sup.1 and R.sup.2 are, independently of one another, H or ##STR3## R.sup.3 is H or --OH in the case where R.sup.4 is --OH, and is H or --OH or a group of the formula III, ##STR4## in the case where R.sup.4 is a group of the formula II, to a process for obtaining them by fermentation, and to their use as surfactants.

Glucose- and sophorose-lipids, a process for their preparation and their

Bacterial strains are capable of the formation of rhamnolipids, which they generate in the culture solution. If bacteria of the type Pseudomonas aeruginosa are employed for the fermentation, these microorganisms synthesize rhamnolipids in a concentration of 70-120 g/l of culture solution. The L-rhamnose can be recovered directly from the culture solution by hydrolysis of the rhamnolipids, i.e. without a complicated separation of the cell material and without isolation of the rhamnolipids before hydrolysis.

Pseudomonas aeruginosa and its use in a process for the biotechnological

The invention relates to .alpha.-L-rhamnosidase, which catalyzes the cleavage of the bond between terminal rhamnose and the aglycone of rhamnose-containing glycosides, a process for preparing it by biotechnological means, and its use for preparing L(+)-rhamnose (6-deoxy-L-mannose).

.alpha.-l-rhamnosidase for obtaining rhamnose, a process for its

Pseudomonas aeruginosa and its use in a process for the biotechnological production of L-rhamnose Bacterial strains are capable of the formation of rhamnolipids, which they generate in the culture solution. If bacteria of the type Pseudomonas aeruginosa are employed for the fermentation, these microorganisms synthesize rhamnolipids in a concentration of 70-120 g/l of culture solution. The L-rhamnose can be recovered directly from the culture solution by hydrolysis of the rhamnolipids, i.e. without a complicated separation of the cell material and without isolation of the rhamnolipids before hydrolysis.

.alpha.-L-Rhamnosidase for obtaining rhamnose, a process for its

Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.

Streptomyces parvullus DSM 3816

Novel streptenols with pharmacological activity, in particular with HMG-CoA-reductase inhibiting activity, can be isolated from the nutrient broth of streptomycetes. These compounds can also be used as synthesis unit for the production of mevilonin analogues.

Streptenols from streptomycetes, and the preparation and use thereof

New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.

Angucyclinones from Streptomycetes, a process for the preparation

The invention relates to elaiophyline derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.1' are identical or different and represent a radical of the formula II/or III ##STR2## in which R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 have the meanings given. The invention furthermore relates to a process for the preparation of these elaiophyline derivatives and also the use of the lattere as medicaments, in particular as anthelmintically acting medicaments.

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Frankfurt am Main, Germany

Carlo Giani