Colgate Palmolive Company

University of Pennsylvania

Carlo Daep

James G Masters

Harsh Mahendra Trivedi

Lynette Anne Zaidel

Carl Myers

Ekta Makwana

Russell Composto

Hyun-Su Lee

Michael Prencipe

Alan Vincent Sorrentino

Robert D'Ambrogio

Ying Yang

Peter Hilliard, Jr

LaTonya Kilpatrick-Liverman

Michael Fitzgerald

Rehana Begum-Gafur

Shamim Alam Ansari

Paul Thomson

Nihal Dogu

Dandan Chen

Luciana Rinaudi Marron

Alexander Rickard

Xiaonan Zhang

Camille Zenobia

Zi Wu

Deon Hines

Derek S Samarian

Gregory Kruse

Divino Rajah

Paul F Thomson

Shamim Ansari

A system for testing biological samples includes a frame having first and second sides and an aperture extending through the frame from the first side to the second side. First and second covers are attached to the first and second sides of the frame to form a well bounded by the frame, the first cover, and the second cover. An electromagnetic imaging device is used to image the biological sample through the first cover. A method is also conceived, wherein a first fluid is supplied to the well, the first fluid including live cells. A biofilm is grown from the live cells. A second fluid is supplied to the well and the biofilm is imaged using the electromagnetic imaging device.

Apparatus, system, and method for testing biological samples

An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

Oral health model for high throughput screen and characterization of oral hygiene products

This invention relates to oral care compositions comprising guanidine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.

Oral care compositions and methods of use

Described herein are methods and systems for identifying a composition having anti-pathogenic activity; evaluating the anti-pathogenic activity of a composition; measuring the metabolic function of a pathogen; and/or comparing the anti-pathogenic performance of a plurality of compositions.

Systems and methods for evaluating the efficacy of anti-pathogenic agents and compositions comprising same

Antimicrobial compositions and methods for depositing or coating the antimicrobial or antibacterial compositions on a substrate to prevent microbial adhesion are provided. The antimicrobial composition may include a cationic polymer having a poly-allylamine backbone. A portion of the poly-allylamine backbone may be functionalized with at least one of a guanidine functional group and a biguanide functional group.

Oral care compositions and methods for anti-attachment polymers and coatings

An ultrasonic system may include: an oral care device including: a head; a plurality of teeth cleaning elements extending from a first side of the head; and an ultrasound module including an ultrasound transceiver positioned in the head, the ultrasound transceiver configured to produce an ultrasound signal on the first side of the head and to generate a detection signal from a reflected ultrasound signal; and a processing module operably coupled to the ultrasound module to receive the detection signal; wherein the processing module includes a programmable processor configured to process the detection signal non-linearly with respect to time by first identifying a first reflection representing a surface of a tooth and then determining whether a second reflection peak is present in the detection signal at a time prior to the first reflection peak, the second reflection peak representing a biofilm on the surface of the tooth.

Ultrasonic system and method for detecting a biofilm on a tooth

Disclosed herein is mucin-coated silica, compositions comprising the same, and methods of promoting the aggregation and/or clearance of oral bacteria using such compositions.

Mucin coated silica for bacterial aggregation

Growing community of inventors

Brooklyn, NY, United States of America

Carlo Daep