Boehringer Mannheim Italia, S.p.a.

F. Hoffmann-la Roche Ag

Cell Therapeutics Europe S.r.l.

Carlo Bugatti

Silvano Spinelli

Mariella Valsecchi

Ernesto Menta

Nicholas P Farrell

Carla Manzotti

Alessandro Pasini

Marco Conti

Ferdinando C Giuliani

Paolo Pavesi

Luisa Del Greco

Fernando Giuliani

A liposome pharmaceutical formulation of the compound of 6,9-bis-[(2-aminoethyl)-amino]benzo[g]isoquinoline-5,10-dione dimaleate, the method for the preparation and the use thereof.

Liposome formulation of 6,9-bis[(2-aminoethyl)-amino]benzo[g]isoquinoline-5, 10-dione dimaleate

Trinuclear cationic platinum complexes having antitumor activity and

##STR1## Platinum (II) complexes of formula (I) where: Am is a monodentate amine, or (Am).sub.2 is a bidentate amine, B represents a straight or branched alkyl residue or a single bond, R is selected from the group of hydrogen, (C.sub.3 -C.sub.8) cycloalkyl, phenyl or naphthyl which may be substituted by halogens (I, Br, Cl, F), trihalomethane, hydroxyl, (C.sub.1 -C.sub.4)-alkoxyl, (C.sub.1 -C.sub.7)-acylamino, (C.sub.1 -C.sub.7)-sulphamido, allyl, phenoxyl, haloalkoxyl, nitro, cyano, azido, with condition that when R is hydrogen B is different from a single bond, Q is a residue of formula --(CH.sub.2).sub.n1 --CR.sub.a R.sub.b --(CH.sub.2).sub.n2 --, 1,2- or 2,3-naphthalene, benzo-1,3-dioxolan-5,6-diyl, substituted or unsubstituted 1,2-phenylene, R.sub.a and R.sub.b are selected independently of each other from the group of hydrogen, allyl, linear or branched (C.sub.1 -C.sub.8)-alkyl, --(CH.sub.2).sub.p OH, --(CH.sub.2 CH.sub.2 O).sub.q --CH.sub.3, or taken together with the carbon atom to which they are bonded form a (C.sub.3 -C.sub.8) cycloalkyl, or heterocyclic tetrahydropyran-4,4-diyl, n.sub.1 and n.sub.2 are independently zero or the integer 1, p is an integer from 2 to 6, and q is an integer from 1-3, X.sup.- is a biocompatible anion such as chloride, bromide, iodide, nitrate, perchlorate, or one equivalent of sulphate or phosphate, or an anion of a monovalent C.sub.1 -C.sub.4 organic acid such as acetate, propionate or chloroacetate, or of an aromatic acid such as benzoate, or of a heteroaromatic acid such as nicotinate are described. The compounds are useful as anti-tumor drugs.

Cis-platinum complexes with chelating amines and sulphinyl carboxylates

Growing community of inventors

Milan, Italy

Carlo Bugatti