Signal Pharmaceuticals, Inc.

Carla M Suto

Jun Wu

Miguel S Barbosa

Leah M Gayo

Cell lines and methods for detecting cytomegalovirus infection and identifying modulators of cytomegalovirus gene expression are disclosed. The cell lines carry an integrated plasmid that contains a reporter gene under the control of a cytomegalovirus promoter. Such cell lines may be used, for example, for specifically identifying HCMV infection in a biological sample.

Reporter cell line system for detecting cytomegalovirus and identifying

Compounds having utility as anti-viral agents in general and, more specifically, to methods for treating a viral condition in an animal are disclosed. The compounds are naphthalene derivatives, and are preferably administered to the patient in the form of a pharmaceutical composition. Viruses treatable by the methods of this invention include viruses of the herpes virus family, such as cytomegalovirus, herpes simplex virus and human lymphotrophic herpes virus.

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San Diego, CA, United States of America

Carla M Suto