Abbott Laboratories Corporation

Carla M Edwards

Leslie A Freiberg

Richard J Pariza

Hugh N Nellans

Larry L Klein

Paul A Lartey

Clinton M Yeung

David J Bacino

Macrocylic lactam compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein A is selected from ##STR2## also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

Macrocyclic lactam prokinetic agents

Macrocylic lactam compounds of formula (i) ##STR1## and pharmaceutically acceptable salts thereof, wherein A is selected from ##STR2## also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

Antibacterial compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein Y is selected from ##STR2## and X is selected from the group consisting of --C(O)--, --C(S)--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- and --C(CH.sub.3).sub.2 --; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

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Evanston, IL, United States of America

Carla M Edwards