The University of Chicago

Janssen Pharmaceuticals, Inc.

Carla Emolo

Olaf Schneewind

Dominique Missiakas

Molly McAdow

Andrea Dedent

Alice G Cheng

Hwan Keun Kim

Jeroen Geurtsen

Mark De Been

Lena Thomer

Dominique M Missiakas

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

Compositions and methods related to antibodies that neutralize coagulase activity duringdisease

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.

Staphylococcal coagulase antigens and methods of their use

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

Compositions and methods related to antibodies to Staphylococcal protein A

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria, in certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa).

Growing community of inventors

Chicago, IL, United States of America

Carla Emolo