Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

Biosparq B.v.

Carla Elisabeth Anna Maria Degenhardt-Langelaan

Johannes Cornelis Maria Marijnissen

Arjan Laurens Van Wuijckhuijse

Charles Eliza Kientz

Willemina Anna Van Den Brink-Kleefsman

Arjan Laurens Wuijckhuijse

The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I), wherein X is chosen from S, O or N, and wherein Rand Rare independently chosen from hydrogen, methyl, methoxy, ethoxy, and propoxy, or wherein Rand Rare taken together to form an optionally substituted aromatic ring structure, optionally comprising one or more heteroatoms, or a tautomeric form thereof. A matrix composition preferably includes the matrix material and an alcohol. The alcohol can be halogenated. The MALDI MS method comprises contacting the analyte with the matrix material or the matrix composition; ionising at least part of the analyte, and separating the ionised components using a mass spectrometer, e.g. TOF-MS. Preferably, bioaerosols are contacted with the matrix material in the gas phase. 

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Delft, Netherlands

Carla Elisabeth Anna Maria Degenhardt-Langelaan