National Institutes of Health, a Component of the US Dept. of Health & Human Services

The United States of America As Represented by the Secretary of

The United States of America As Represented by the Department of Health

National Institutes of Health

The Government of the United States of America, As Represented by the

Carl W Saxinger

Robert C Gallo

Flossie Wong-Staal

Syed Zaki Salahuddin

Dharam V Ablashi

Steven F Josephs

Steven Francis Josephs

Syed Z Salahuddin

The present invention provides, among other things, a polypeptide that binds with the gp120 envelope protein of HIV, in particular HIV-1, under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a composition comprising such a polypeptide or nucleic acid or an antibody and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of making an antibody to gp120, and a method of removing HIV from a bodily fluid.

Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use

The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.

Polypeptides comprising IL-6 ligand binding receptor domains

A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.

Antibodies against human herpes virus-6(HHV-6) and method of use

The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt. thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.

Polypeptides comprising IL-6 ligand-binding receptor domains

Antibodies against human herpesvirus-6(HHV-6) and method of use

An automated peptide design and synthesis method is provided, wherein peptides are synthesized on interior, inward facing surfaces of reservoirs formed in a solvent resistant substrate. Novel substrates, as well as novel solutions for storing protected carboxyl terminal amino acids, are also provided.

Automated Peptide design and synthesis

Human herpesvirus-6 (HHV-6) isolation and products

Human herpesvirus-6(HHV-6)Isolution and Products

Growing community of inventors

Bethesda, MD, United States of America

Carl W Saxinger