Orpegen Medizinisch-molekularbiologische Forschungsgesellschaft M.b.h.

Orpegen Pharma Gmbh

Glycotope Biotechnology Gmbh

Orpegen Pharma Gesellschaft Für Biotechnologische Forschung, Entwicklung Und Produktion M.b.h.

Carl Thomas Nebe

Werner Nader

Karin Hartmann

Gerhard Nebe

Hartmann Karin

Christian Birr

A method is described for determining the chemotactic activity of leukocytes in a sample, in which method the expression of a cell adhesion molecule is determined.

Chemotaxis diagnostic

The present invention concerns a method for determining the degranulation activity of basophilic granulocytes in a sample as well as a reagent kit that is suitable for this. Furthermore the invention also concerns a method for diagnosing allergic hypersensitivity and for monitoring the response to a hyposensitization therapy.

Basophil degranulation test

The present invention provides a process for the control of a biological rification stage of the aerobic activated sludge type, wherein at least one of the micro-organisms most frequently present in the activated sludge is continuously monitored with regard to the amount thereof in that, in a representative sample from the activated sludge and/or from the inlet of the activated sludge tank, this micro-organism is bound to fluorescence-labelled antibodies directed against the chosen micro-organism or this micro-organism is allowed to react with a fluorogenic substrate by means of a special metabolic ability, the amount of the thus fluorescence-labelled micro-organism is determined by flow cytometry and, at the same time, the total amount of the micro-organism present is determined by scattered light measurement and/or coloration of the DNA and, depending upon the measurement values thus obtained, the amount of at least one particular micro-organism and/or the growth conditions for this micro-organism is regulated.

Method for control and monitoring of activated sludge in a biological

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Ladenburg, Germany

Carl Thomas Nebe