Wyeth

Pfizer Corporation

Carl Ralph Flannery

Christopher John Corcoran

Lisa Anne Collins-Racie

Bethany Annis Freeman

Edward R LaVallie

Lisa A Racie

Michael J Agostino

Katy Evangelia Georgiadis

Thomas E McDonagh

Weilan Zeng

Lisa Anne Racie

Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.

Polynucleotides encoding recombinant lubricin molecules and uses thereof

Recombinant lubricin molecules and uses thereof

Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura are provided.

The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.

Modified ADAMTS4 molecules and method of use thereof

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

Aggrecanase molecules

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Acton, MA, United States of America

Carl Ralph Flannery