Mannkind Corporation

Becton Dickinson and Company Limited

Bio-plexus, Inc.

Ebio Nutritional Sciences LLC

Other

Carl R Sahi

John M Polidoro

Chad C Smutney

P Spencer Kinsey

Benoit Adamo

Dennis Overfield

Scott McLean

Kenneth G Powell

Anthony Bryant

Scott Mclean

Vincent J Sullivan

Matthew S Ferriter

Ge Jiang

Mark T Marino

Christine Billings

Charles D Shermer

Kelly Sullivan Kraft

Richard G Holdaway

Karla Somerville

Richard S Kearns

David S Chapin

Alexander George Lastovich

Brendan F Laurenzi

Daniel M Stipe

James Fentress

Alfred Mann

Jeff M Moss

Melody Kuroda

Mark Ennis Ketner

Alexander K Jones

Mark J Burzynski

Dakshinamurthy Devanga Chinta

Tom He

Ed Browka

Anthony J Bryant

Dennis O Overfield

Grayson Walker Stowell

Marshall L Grant

Paul Menkin

John M Seifert

Richard R Phillips

Marius Walter Hauri

Kevin J Seifert

Gregory F Biancardi

Chester Fudge

Spencer P Kinsey

Dennis Overfiled

Walter Hauri

Jeffrey J Lamo

Dennis Overfileld

Jeff Moss

James K Fentress

Jim Fentress

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

Dry powder inhaler and system for drug delivery

A sweetener composition includes a plurality of assembled particles including natural, non-nutritive sweetener molecules, organic scaffold particles and at least one additive. The natural, non-nutritive sweetener molecules include hydrophilic moieties and hydrophobic moieties. The organic scaffold particles include at least one compositional component including a lipid. The at least one additive includes a surfactant, a stabilizer, an emulsifier, a hydrocolloidal material, a ripening inhibitor, a weighting agent, an excipient, a flavoring agent, a coloring agent, a preservative, a masking agent, a texture enhancer, or a combination thereof. Methods of making the sweetener composition are also described.

Sweetener composition and methods of making it

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.

Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

Interactive apparatus and method for real-time profiling of inhalation efforts

A sweetener composition includes a plurality of assembled particles including natural, non-nutritive sweetener molecules and organic scaffold particles. The natural, non-nutritive sweetener molecules include hydrophilic moieties and hydrophobic moieties, the organic scaffold particles include at least one compositional component including a C6-C10 medium chain glyceride, and the C6-C10 medium chain glyceride includes at least 20 wt % of the total lipid content of the composition. Methods of making the sweetener composition are also described.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.

Dry powder drug delivery system

An apparatus, a closed-loop system and method for measuring the resistance of inhalation systems and/or devices are disclosed.

Apparatus, system and method for measuring resistance of an inhaler

A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

Reconstituting infusion device

An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.

Apparatus and method for simulating inhalation efforts

Growing community of inventors

Coventry, CT, United States of America

Carl R Sahi