Tlc Biopharmaceuticals, Inc.

Taiwan Liposome Company, Ltd.

Carl Oscar Brown

Sheue-Fang Shih

Yun-Long Tseng

Yi-yu Lin

Hao-wen Kao

Wan-Ni Yu

Min-Wen Kuo

Pei-hsien Hu

Tien-Tzu Tai

Keelung Hong

Hui-ting Wang

Weenee Yeun Ng Jao

Provided is a method for treating joint pain in a subject with arthritis. The method comprises administering to the subject with a determined grade of osteoarthritis an effective amount of intra-articular corticosteroid or pharmaceutically acceptable salt thereof in a pharmaceutical composition. Achieved is robustness of the efficacy response to a treatment with intra-articular corticosteroid in predetermined subgroups of the intent-to-treat population.

Pharmaceutical composition of intra-articular corticosteroid for pain control

Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.

Pharmaceutical compositions for use in treating pain

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Taipei, Taiwan

Carl Oscar Brown