3-dimensional Pharmaceuticals, Inc.

Carl L Illig

Tianbao Lu

Richard M Soll

Bruce Edward Tomczuk

Roger Francis Bone

Nalin L Subasinghe

Cynthia L Fedde

Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R.sup.1 -R.sup.4, R.sup.6 -R.sup.9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.

Amidinohydrazones as protease inhibitors

The present invention is directed to novel compounds that are thrombin inhibitors and are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The compounds have the general Formula I: ##STR1## and pharmaceutically acceptable salts thereof; wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n and m are defined herein.

Thrombin inhibitors

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Phoenixville, PA, United States of America

Carl L Illig