Wisconsin Alumni Research Foundation

Carl J Malizio

Eric Arthur Johnson

Michael C Goodnough

William Howard Tepp

Alan B Scott

Hiroshi Sugiyama

A method of targeting therapeutic molecules to motor neurons is disclosed. In one embodiment, this method comprises the steps of (a) synthesizing a prodrug comprising a therapeutic molecule covalently bound to a polymeric delivery vehicle, and (b) conjugating the prodrug to a botulinum neurotoxin heavy chain.

Method of targeting pharmaceuticals to motor neurons

A chimeric toxin is disclosed. In a preferred embodiment, the chimeric toxin comprises a botulinal neurotoxin heavy chain and non-clostridial toxin chain. A method of creating a chimeric toxin is also disclosed. The chimeric toxin will have utility for pharmacological treatment of neurological disorders.

Chimeric toxins

The isolation and purification of type G botulinum neurotoxin and complexes thereof is disclosed. Compositions containing the type G neurotoxin and the preparation of a type G toxoid are also disclosed.

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Madison, WI, United States of America

Carl J Malizio