Medimmune Limited

Advanced Technologies (cambridge) Limited

British American Tobacco Limited

Carl Innes Webster

Lutz Jermutus

Albert George Thom

Jonathan P Hatcher

John Clinton Gray

Jagdeep Singh Sandhu

Jagdeep Singh University Of Illinois Sandhu

The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries.

Blood brain barrier transport molecules and uses thereof

The invention provides enhancers for one or more gene promoters, which enhancers are nucleotide sequences rich in A and T bases, the total amount of A and T bases comprising more than 50% of the nucleotide sequence. Particular sequences are identified from the pea plastocyanin promoter which are active as enhancers, as is a solely A/T nucleotide sequence, and methods of carrying out the invention are described.

Enhancer-increased gene expression in plants

Growing community of inventors

Cambridge, United Kingdom

Carl Innes Webster