Centre National De La Recherche Scientifique

Vanderbilt University

Carl Hirschie Johnson

Laurent Meijer

Leandros Skaltsounis

Qing Xu

Philip D Weyman

Emmanuel Mikros

Yao Xu

Prokopios Magiatis

A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described.

Manipulating the circadian clock to increase gene expression

Indirubin derivatives of formula (I) wherein R represents -(A)- Ror &#x2014;CO&#x2014;N(R,R) with &#x2022;A being C1-C5 alkylene group, optionally substituted by one or several Aradical, Abeing an halogen Br, OH, ORor NH, Rbeing C1-C5 alkyl; &#x2014;Rbeing halogen, OH, N(R, R); Rand R, identical or different, being C1-C5 alkyl, optionally substituted by Asuch as above defined, or Rand Rare part of a cycle with 5 or 6 elements optionally comprising another heteroatom such as O or N; &#x2022;n=1&#x2212;5. It also relates to the biological application thereof. 

3',6-substituted indirubins and their biological applications

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Nashville, TN, United States of America

Carl Hirschie Johnson