Prolinx Incorporated

Carl H D Weissman

Mark L Stolowitz

Robert J Kaiser

Karin A Hughes

Douglas A Spicer

James E Mahoney

Amy L Springer

This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the unincorporated dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.

Removal of dye-labeled dideoxy terminators from DNA sequencing reactions

This invention provides methods for removing unincorporated fluorescent dye-labeled molecules from a mixture that includes fluorescently-labeled polynucleotides and the unincorporated fluorescent dye-labeled molecules. The methods involve adsorbing the unincorporated fluorescent dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.

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Seattle, WA, United States of America

Carl H D Weissman