Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Centro Nacional De Investigaciones Oncologicas (cnio)

Carl-Gustave Pierre Saluste

Sonia Martínez González

Jose Ignacio Martín Hernando

Antonio Rodríguez Hergueta

Joaquín Pastor Fernández

Carmen Blanco Aparicio

Ana Isabel Hernández Higueras

Francisco Javier Ramos Lima

Ana Maria Garcia Collazo

Beatriz Noya Marino

Antonio Salgado Serrano

Esther Gonzalez Cantalapiedra

Esther González Cantalapiedra

Joaquin Pastor Fernandez

Jose Ignacio Martin Hernando

José Ignacio MARTÍN Hernando

Beatriz Noya Mariño

Ana Isabel Hernandez Higueras

Antonio Rodriguez Hergueta

There is provided compounds of formula (I), wherein R, R, Rand Rhave meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I). 

Tricyclic compounds for use as kinase inhibitors

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Madrid, Spain

Carl-Gustave Pierre Saluste