Epizyme, Inc.

Carl Eric Schwartz

Richard Chesworth

Kevin Wayne Kuntz

Russell Colyn Petter

Lorna Helen Mitchell

Megan Alene Cloonan Foley

Jennifer C Petter

The present disclosure provides provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer. 

Isoxazole carboxamides as irreversible SMYD inhibitors

The present disclosure provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer. 

Growing community of inventors

Lynnfield, MA, United States of America

Carl Eric Schwartz