Aileron Therapeutics, Inc.

Google Inc.

Carl Elkin

Huw M Nash

Vincent Guerlavais

Eric Feyfant

Tomi K Sawyer

Bradford Graves

David Kogan

Warren Wang

Carlos David Correa Ocampo

Noriyuki Kawahata

Bradford J Graves

Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.

Peptidomimetic macrocycles

Aspects of the disclosure relate to a method for providing an animated presentation. The method includes identifying a geographic area and identifying solar flux for the geographic area. A plurality of images of the geographic area then is generated to display the solar flux. Each image in the plurality of images displays solar flux at different points in time of a day. The animated presentation is generated by displaying the plurality of images in chronological order with a transition between images in the plurality of images and provided for display on a display to a user.

Determining and presenting solar flux information

The present invention provides peptidomimetic macrocycles capable of regulating HIF1&#x3b1; and methods of using such macrocycles for the treatment of diseases.

Peptidomimetic macrocycles and use thereof in regulating HIF1alpha

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Arlington, MA, United States of America

Carl Elkin