A. H. Robins Company, Incorporated

Carl D Lunsford

Ying-Ho Chen

Albert D Cale, Jr

Reevis S Alphin

Novel 1-aryloxy-4-amino-2-butanols of the formula

1-aryloxy-4-amino-2-butanols

Certain aryloxy-4-chloro-2-butanol intermediates

1-Aryloxy-4-amino-2-butanols

1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof

N-(4-Pyrazolidinyl)benzamides having the formula ##STR1## and their amino precursors are disclosed wherein R is lower alkyl, lower cycloalkyl or phenyllower-alkyl; R.sup.1 is lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R.sup.2 is hydrogen, lower alkyl or phenyl; R.sup.3 is hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulfamoyl or actamido, R.sup.3 can be the same radical or different radicals; n is an integer from zero to three inclusive, and pharmaceutically acceptable acid addition salts thereof. The compounds have anti-emetic and gastric emptying properties.

N-(4-Pyrazolidinyl)benzamides and their amino precursors

Novel amides of norfenfluramine having the formula ##STR1## wherein R is selected from the group consisting of alkyl and alkenyl radicals having 12 to 22 carbon atoms and compositions and methods for combating atherosclerosis and hypercholesteremia, with beneficial side effects useful for combating obesity in atherosclerotic subjects are disclosed. The compounds lower lipid values and simultaneously inhibit appetite and reduce weight gain from ingested food with minimal side effects.

Fatty acid amides of norfenfluramine and compositions and methods thereof

Pyrrolidinyl benzamides represented by the formula: ##STR1## wherein R is methyl or cycloalkyl having 3 to 12 carbon atoms; R.sup.1 is hydrogen or methyl and the pharmaceutically acceptable salts thereof are disclosed in methods which increase the rate of gastric emptying in mammals.

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Richmond, VA, United States of America

Carl D Lunsford