Radiometer A/s

Carl C Holbek

Soren K Sorensen

A stable synthetic water based reference liquid for quality control and/or calibration of blood gas measuring equipment, said liquid being enclosed in a gas-tight container and containing HCO.sub.3.sup.- ions, H.sup.+ ions, CO.sub.2 gas, and O.sub.2 gas plus an additional pH buffer system different from the pH buffer system constituted by the HCO.sub.3.sup.- ions and the CO.sub.2 gas, said liquid showing, at a fixed temperature, known pH, pCO.sub.2 and pO.sub.2 values, said liquid additionally containing oxygen reversibly contained in a dispersed non-proteinaceous organic substance which shows higher solubility for oxygen than does water, and, optionally, a coloring component showing maximum or significant absorption at about 500 nm, said organic substance being

Reference liquid for blood gas equipment

A reference liquid for the calibration and/or quality control of blood gas analyzers. The reference liquid comprises an aqueous phase and either polymer-coated microcapsules containing at least one organic substance functioning as oxygen carrier, or porous particles of a solid substance functioning as oxygen carrier. An example of the polymer-coated microcapsules is nylon-coated microcapsules containing a mixture of perfluorotributyl amine and isooctane. An example of the porous particles of a solid substance is particles of porous silicone rubber.

A package containing a reference liquid for the calibration and/or quality control of blood gas analyzers. The reference liquid is enclosed in a flexible, gas-tight container without any gas bubbles in the container, and to avoid any danger of formation of gas bubbles, the total gas pressure in the liquid is kept below 600 mm Hg at 37.degree. C. The container is preferably a laminate bag of aluminum foil with interior layer of heat sealable plastic of low gas permeability, preferably a polyacrylonitrile copolymer.

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Allerod, Denmark

Carl C Holbek