Pfizer Corporation

Carl B Ziegler, Jr

George Joseph Quallich

Evgenyi Y Shalaev

Antone John deBettencourt, Iii

Michael Anthony Letavic

Hengmiao Cheng

Peter Bertinato

Brian S Bronk

Peter Robert Rose

Jason K Dutra

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Process for forming amorphous atorvastatin

This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.

C11 carbamates of macrolide antibacterials

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East Lyme, CT, United States of America

Carl B Ziegler, Jr