Akzona Incorporated

Carl B Linnecke

Stephen B Friedman

Daniel Wong

A novel combination and a method are disclosed for detecting and measuring a predetermined substance capable of being specifically bound. The combination comprises a novel adapter which eliminates contact of a light conducting and receiving probe with the sample. The novel combination comprises (1) a fiber optic colorimeter comprising a light source, a means for detecting and measuring light, and a probe containing a plurality of optic fibers including a first light conducting means for conducting light from the light source of the colorimeter to a test sample and a second light conducting means for conducting light from the test sample to the means for detecting and measuring light and (2) a microplate having one or more wells, each of which is adapted to contain a liquid test sample, for use in a predetermined colorimetric medical diagnostic test, wherein a reflective surface is disposed below the bottom of the well of said microplate, said well is adapted to accommodate the probe of said fiber optic colorimeter, and wherein said probe includes an attachment means joinable in a close-fitting engagement with an upper portion of each well in said microplate, the attachment means not engaging said liquid sample. The method of the invention is especially suitable for rapid manual examination of sample wells in microplates.

Method and apparatus for specific binding substances

A test card adapted for the performance of an immunochemical diagnostic or serological test thereon comprises a test surface member and a covering member foldable thereon, the covering member being provided with circular convex windows which when folded over are in registry with circular test areas on the test surface member, permitting visual observation of test results, the inner surface of the covering member having adhered thereto a continuous sheet of an absorbent material which becomes transparent upon contact with a liquid, said sheet extending across the windows and permitting viewing of the test results when the test card is closed. Fixed to both surfaces of the absorbent material is a film of double sided adhesive. This adhesive covers the entire absorbent sheet on both sides except for cut-out areas in registry with the transparent window and reaction area. The adhesive on one side bonds the absorbent material to the cover element. On the other side it is bound to the absorbent material and covered by a peel-away element. This peel-away element is removed prior to attaching the cover element to the reaction bearing element. The card may be used, for example, for blood group typing.

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Arcadia, CA, United States of America

Carl B Linnecke