Musc Foundation for Research Development

Carl Atkinson

Satish N Nadig

Ann-Marie Broome

Suraj K Dixit

Stephen Tomlinson

Danh T Tran

Suraj Dixit

Songqing He

Satish Nadig

Provided herein is a formulation to pre-treat an organ prior to transplantation and for inducing mitochondrial morphological alterations.

Organ preconditioning formulation with mitochondrial elongating agents

Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.

Donor organ pre-treatment formulation

Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

Targeted nanocarriers for the administration of immunosuppressive agents

Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.

Growing community of inventors

Mt. Pleasant, SC, United States of America

Carl Atkinson