Gilead Sciences, Inc.

Amygdala Neurosciences, Inc.

Carina E Cannizzaro

Jennifer R Zhang

James Ming Chen

William John Watkins

Aesop Cho

Thorsten A Kirschberg

Lee Shun Chong

Sundaramoorthi Swaminathan

Maria Fardis

Xiaowu Chen

Richard L Mackman

Hyung-Jung Pyun

Adrian S Ray

Christopher P Lee

John O Link

Scott D Schroeder

Winston C Tse

David A Oare

Qi Liu

Steven S Bondy

Alan X Huang

Jeff A Zablocki

Choung U Kim

Michael Graupe

Chandrasekar Venkataramani

Juan A Guerrero

Constantine G Boojamra

David Y Markevitch

Robert G Strickley

Yafan Lu

Vidya K Prasad

Ralph F Hirschmann

Manoj C Desai

William A Lee

Haolun Jin

Yunfeng Eric Hu

Peter H Nelson

Randall Halcomb

Chien-Hung Chou

Rosemarie Sherlock

Kuei-Ying Lin

Chien-hung Chou

Michael L Mitchell

Lianhong Xu

Lijun Zhang

Steven H Krawczyk

Craig S Gibbs

Rosemarie O'Shea

Zheng-Yu Yang

Randall L Halcomb

Sundaramoorthi Swaninathan

Qui Liu

Robert G Stickley

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus. 

Compounds for the treatment of HIV

Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.

Compounds for the treatment of addiction

Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Therapeutic compounds

The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral phosphonate analogs

Disclosed are novel compounds having the structure of Formula (I): which are useful for treating a human for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.

Growing community of inventors

Foster City, CA, United States of America

Carina E Cannizzaro