The United States Government As Represented by the Department of Veterans Affairs

The City University of New York

Saint Louis University

Cari Orth

Maureen J Donlin

Bahaa Elgendy

Feng Cao

In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R, R, and Rare as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of, andspecies.

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St. Louis, MO, United States of America

Cari Orth