Johns Hopkins University

University of Liverpool

Caren Laura Freel Meyers

Douglas Robinson

Alexandra Surcel

Win Pin Ng

Steven Paul Rannard

Andrew Owen

David J Meyers

James Hobson

Charles Williams Flexner

Ryan J Vierling

Marie Webster

Paul Curley

Marco Siccardi

Amer Al-Khouja

Francine Morris

Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition. comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:

Treating and preventing diseases by modulating cell mechanics

The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

Prodrug compositions

Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula: 

Novel inhibitors of DXP synthase and methods of use thereof are disclosed.

Inhibitors of DXP synthase and methods of use thereof

Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.

Bisphosphonamidate prodrugs and uses thereof

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Baltimore, MD, United States of America

Caren Laura Freel Meyers