Emory University

Neurop, Inc.

Cara Mosley

Dennis C Liotta

James P Snyder

Stephen F Traynelis

Lawrence J Wilson

Yesim Altas Tahirovic

Raymond J Dingledine

Scott James Myers

Scott Myers

Lawrence Wilson

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein:

NMDA receptor antagonists for neuroprotection

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein:each (L)-Aris a substituted or unsubstituted, mono or bicyclic aryl or heteroaryl; W is a bond, alkyl, or alkenyl; X is a bond, NRor O and each Rand Ris independently H, alkyl, alkenyl or aralkyl or Rand Rtaken together form a 5-8 membered ring; RRare selected from certain specific substituents or a carbonyl; Y is a bond, O, S, SO, SO, CH, NH, N(alkyl), or NHC(&#x2550;O); and Z is OH, NRR, NRSO(alkyl), NRC(O)NRR, NRC(O)O(alkyl), NR-dihydrothiazole, or NR-dihydroimidazole or wherein Z can fuse with Arto form selected heterocycles.

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Atlanta, GA, United States of America

Cara Mosley