Zheijiang Jiuzhou Pharmaceutical Co., Ltd.

Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

Canming Zhang

Shen Li

Qilin Zhou

Lixin Wang

Shoufei Zhu

The present invention relates to a preparation method of carboxylic acids with optical activity, particularly, publishes that very useful chiral carboxylic acids can be obtained by the asymmetric catalytic hydrogenation of tri-substituted &#x3b1;,&#x3b2;-unsaturated carboxylic acids, with the complexes of the chiral phosphor nitrogen ligands and iridium used as the catalysts which show high activity and enantioselectivity (up to 99.8% ee), thus provides a more efficient method with higher enantioselectivity for asymmetric catalytic hydrogenation of chiral carboxylic acid-like compounds, and has important application value to asymmetric hydrogenation of chiral carboxylic acids.

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Tianjin, China

Canming Zhang